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Tomatidine . HCl

Negative control for Cyclopamine
BML-GR335-0025 25 mg 58.00 USD
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Replaces Prod. #: ALX-350-377

Steroidal alkaloid structurally similar to cyclopamine (Prod. No. ALX-430-159) but does not inhibit the hedgehog (shh) pathway. May be used as a negative control for jervine (Prod. No. ALX-350-378).

Product Specification

Formula:C27H45NO2 . HCl
Source:Tomato leaves
Purity:≥90% (TLC)
Appearance:Off-white solid
Solubility:Soluble in DMSO (2mg/ml), 100% ethanol (2.5mg/ml) or dimethyl formamide (2mg/ml). Slight warming may be required.
Long Term Storage:-20°C
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C
Handling:Protect from light. After reconstitution, prepare aliquots and store at -20°C.
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Product Literature References

Induction of MITF expression in human cholangiocarcinoma cells and hepatocellular carcinoma cells by cyclopamine, an inhibitor of the Hedgehog signaling: P. Samatiwar, et al.; Biochem. Biophys. Res. Commun. 470, 144 (2016), Application(s): Cell culture, Abstract;
Hedgehog signaling between cancer cells and hepatic stellate cells in promoting cholangiocarcinoma: Y. Kim, et al.; Ann. Surg. Oncol. 21, 2684 (2014), Abstract;
Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy: M.C. Dyle, et al.; J. Biol. Chem. 289, 14913 (2014), Abstract; Full Text
Gli2 expression and human bladder transitional carcinoma cell invasiveness: C.W. Mechlin, et al.; J. Urol. 184, 344 (2010), Abstract;
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis: S.P. Thayer et al.; Nature 425, 851 (2003), Abstract;
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer: D.N. Watkins et al.; Nature 422, 313 (2003), Abstract;
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours: D.M. Berman et al.; Nature 425, 846 (2003), Abstract;
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor: S.K. Kim et al.; PNAS 95, 13036 (1998), Abstract;
Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper et al.; Science 280, 1603 (1998), Abstract;

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