Online Purchasing Account You are logged on as Guest. Login Register a New Account Shopping cart (Empty)

Tomatidine . HCl

Negative control for Cyclopamine



BML-GR335-0025	25 mg	76.00 USD
Do you need bulk/larger quantities?

Replaces Prod. #: ALX-350-377

Steroidal alkaloid structurally similar to cyclopamine (Prod. No. ALX-430-159) but does not inhibit the hedgehog (shh) pathway. May be used as a negative control for jervine (Prod. No. ALX-350-378).

Product Details

Formula:	C₂₇H₄₅NO₂ . HCl

MW:	452.1

Source:	Tomato leaves

CAS:	6192-62-7

Purity:	≥90% (TLC)

Appearance:	Off-white solid

Solubility:	Soluble in DMSO (2mg/ml), 100% ethanol (2.5mg/ml) or dimethyl formamide (2mg/ml). Slight warming may be required.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Use/Stability:	Stock solutions are stable for up to 3 months when stored at -20°C

Handling:	Protect from light. After reconstitution, prepare aliquots and store at -20°C.

Regulatory Status:	RUO - Research Use Only

Please mouse over

Product Literature References

Induction of MITF expression in human cholangiocarcinoma cells and hepatocellular carcinoma cells by cyclopamine, an inhibitor of the Hedgehog signaling: P. Samatiwar, et al.; Biochem. Biophys. Res. Commun. 470, 144 (2016), Application(s): Cell culture, Abstract;

Hedgehog signaling between cancer cells and hepatic stellate cells in promoting cholangiocarcinoma: Y. Kim, et al.; Ann. Surg. Oncol. 21, 2684 (2014), Abstract;

Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy: M.C. Dyle, et al.; J. Biol. Chem. 289, 14913 (2014), Abstract; Full Text

Gli2 expression and human bladder transitional carcinoma cell invasiveness: C.W. Mechlin, et al.; J. Urol. 184, 344 (2010), Abstract;

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis: S.P. Thayer et al.; Nature 425, 851 (2003), Abstract;

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer: D.N. Watkins et al.; Nature 422, 313 (2003), Abstract;

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours: D.M. Berman et al.; Nature 425, 846 (2003), Abstract;

Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor: S.K. Kim et al.; PNAS 95, 13036 (1998), Abstract;

Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper et al.; Science 280, 1603 (1998), Abstract;