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ICRF-193

Topoisomerase inhibitor
 
BML-GR332-0001 1 mg 123.00 USD
 
BML-GR332-0005 5 mg 504.00 USD
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A topoisomerase II inhibitor that does not cause DNA damage. Induces apoptosis in several cell lines including K562 and Molt-4 cells. Induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.

Product Specification

Alternative Name:Meso-4,4'-(3,2-butanediyl)-bis(2,6-piperazinedione)
 
Formula:C12H18N4O4
 
MW:282.3
 
CAS:21416-68-2
 
Purity:≥95% (HPLC)
 
Appearance:Off-white to pale yellow solid.
 
MeltingPoint:298-299°C
 
Solubility:Soluble in DMSO (4mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase: P. B. Deming, et al.; J. Biol. Chem. 277, 36832 (2002), Abstract; Full Text
The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells: B. B. Hasinoff, et al.; Mol. Pharmacol. 59, 453 (2001), Abstract; Full Text
Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs: K. Iguchi, et al.; Biochem. Pharmacol. 57, 1105 (1999), Abstract;

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