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Splitomicin

HDAC inhibitor
 
BML-GR331-0005 5 mg 103.00 USD
 
BML-GR331-0025 25 mg 422.00 USD
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Replaces Prod. #: ALX-270-380

Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50=60µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.

Product Specification

Formula:C13H10O2
 
MW:198.2
 
CAS:5690-03-9
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
 
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Product Literature References

Identification and characterization of novel sirtuin inhibitor scaffolds: B.D. Sanders, et al.; Bioorg. Med. Chem. 17, 7031 (2009), Abstract;
Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast: M. Hirao, et al.; J. Biol. Chem. 278, 52773 (2003), Abstract;
Identification of a small molecule inhibitor of Sir2p: A. Bedalov, et al.; PNAS 98, 15113 (2001), Abstract; Full Text

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