Replaces Prod. #: ALX-270-298
Inhibitor of histone deacetylase (HDAC) (HDAC1 and 3: IC50~0.6µM; HDAC8: IC50~1µM) with lower toxicity than trichostatin A (Prod. No. BML-GR309). Inhibits tumor growth in vitro and in vivo and, in conjunction with 5-aza-2’-deoxycytidine (Prod. No. ALX-480-096), enhances expression of estrogen receptor α. Optimal concentration 2-2.5μg/ml (6-8μM). A negative control is available (Prod. No. BML-GR327).
Product Details
| Alternative Name: | 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide |
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| Formula: | C18H18N2O4 |
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| MW: | 326.4 |
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| CAS: | 287383-59-9 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (4mg/ml), ethanol (0.3mg/ml) or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from air. Store under inert gas |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro
6, ENEURO.0263-18.2019 (2019),
Abstract;
Full Text
Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem.
286, 22211 (2011),
Abstract;
Full Text
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine: J.C. Keen, et al.; Breast Cancer Res. Treat.
81, 177 (2003),
Abstract;
Identification of novel isoform-selective inhibitors within class I histone deacetylases: E. Hu, et al.; J. Pharmacol. Exp. Ther.
307, 720 (2003),
Abstract;
A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library: G.H. Su, et al.; Cancer Res.
60, 3137 (2000),
Abstract;
Full Text
