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Pifithrin-α

p53 inhibitor
 
BML-GR325-0005 5 mg 75.00 USD
 
BML-GR325-0025 25 mg 317.00 USD
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Replaces Prod. #: ALX-270-270

Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Suppresses self-renewal of embryonic stem cells.

Product Specification

Alternative Name:1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr, PFT-α
 
Formula:C16H18N2OS . HBr
 
MW:367.3
 
CAS:63208-82-2
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light. Keep under inert gas. Hygroscopic.
 
ALX-270-270
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ALX-270-270

Product Literature References

Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J. Biol. Chem. 279, 30195 (2004), Abstract;
Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes: F.U. Muller, et al.; Cell Death Differ. 11, 485 (2004), Abstract;
Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio: D. Javelaud & F. Besancon; J. Biol. Chem. 277, 37949 (2002), Abstract; Full Text
Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons: C. Alves da Costa, et al.; PNAS 99, 4043 (2002), Abstract;
Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes: A. Lakkaraju, et al.; J. Biol. Chem. 276, 32000 (2001), Abstract; Full Text
Suppression of p53: a new approach to overcome side effects of antitumor therapy: E.A. Komarova & A.V. Gudkov; Biochemistry (Mosc) 65, 41 (2000), (Review), Abstract; Full Text
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999), Abstract;
Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999), Abstract;

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