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Monastrol

Kinesin inhibitor
 
BML-GR322-0005 5 mg 134.00 USD
 
BML-GR322-0025 25 mg 522.00 USD
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Replaces Prod. #: ALX-430-094

Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.

Product Specification

Alternative Name:4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester
 
Formula:C14H16N2O3S
 
MW:292.4
 
CAS:329689-23-8
 
Purity:≥98% (TLC)
 
Appearance:White to light yellow solid.
 
MeltingPoint:184-186°C
 
Solubility:Soluble in DMSO (20mg/ml) or 100% ethanol (4mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light.
 
ALX-430-094
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ALX-430-094

Product Literature References

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524: A.P. Baron, et al.; eLife 5, e12187 (2016), Application(s): Cell culture, Abstract;
Cytokinetic failure-induced tetraploidy develops into aneuploidy, triggering skin aging in phospho-vimentin deficient mice: H. Tanaka, et al.; J. Biol. Chem. 290, 12984 (2015), Application(s): Cell Culture using mouse fibroblasts, Abstract; Full Text
Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One 8, e72886 (2013), Abstract; Full Text
A pathway of structural changes produced by monastrol binding to Eg5: Z. Maliga, et al.; J. Biol. Chem. 281, 7977 (2006), Abstract;
Allosteric inhibition of kinesin-5 modulates its processive directional motility: B.H. Kwok, et al.; Nat. Chem. Biol. 2, 480 (2006), Abstract;
Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein: T. Peters, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 372, 291 (2006), Abstract;
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures: S.Y. Yoon, et al.; Cell Motil. Cytoskeleton 60, 181 (2005), Abstract;
Inhibition of a mitotic motor protein: where, how, and conformational consequences: Y. Yan, et al.; J. Mol. Biol. 335, 547 (2004), Abstract;
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5: Z. Maliga, et al.; Chem. Biol. 9, 989 (2002), Abstract;
A combinatorial approach to recognition of chirality: preparation of highly enantioselective aryl-dihydropyrimidine selectors for chiral HPLC: K. Lewandowski, et al.; J. Comb. Chem. 1, 105 (1999), Abstract;
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen: T.U. Mayer, et al.; Science 286, 971 (1999), Abstract;

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