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HC Toxin

HDAC inhibitor
 
BML-GR320-0001 1 mg 208.00 USD
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Replaces Prod. #: ALX-630-102

A potent, cell-permeable histone deacetylase (HDAC) inhibitor. Inhibits HDACs in maize, Physarum and chicken. IC50=30nM for E. tenella HDAC. Displays antiprotozoal and antineoplastic activity. Induces expression of the γ-globin gene in erythroid cells. Shows antimitogenic activities. Induces cell cycle arrest and apoptosis in tumor cells.

Product Specification

Alternative Name:Cyclo-(D-Pro-L-Ala-D-Ala-L-2-amino-8-oxo-9,10-epoxydecanoic acid)
 
Formula:C21H32N4O6
 
MW:436.5
 
CAS:83209-65-8
 
Purity:≥98% (TLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Technical Info/Product Notes:Toxic against maize.
 
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Product Literature References

Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem. 286, 22211 (2011), Abstract; Full Text
HC-toxin: J.D. Walton; Phytochemistry 67, 1406 (2006), Abstract;
Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells: K.E. Joung et al.; Arch. Pharm. Res. 27, 640 (2004), Abstract;
Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells: K.N. Min et al.; Arch. Pharm. Res. 27, 554 (2004), Abstract;
Induction of gamma-globin by histone deacetylase inhibitors: P.G. McCaffrey, et al.; Blood 90, 2075 (1997), Abstract; Full Text
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase: S.J. Darkin-Rattray, et al.; PNAS 93, 13143 (1996), Abstract; Full Text
Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum: G. Brosch, et al.; Plant Cell 7, 1941 (1995), Abstract;
Isolation and Biological Activities of Four Selective Toxins from Helminthosporium carbonum: J.B. Rasmussen & R.P. Scheffer; Plant Physiol. 86, 187 (1988), Abstract;
The structure and conformation of HC-toxin: M. Kawai, et al.; Biochem. Biophys. Res. Commun. 111, 398 (1983), Abstract;

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