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United States 

Doxorubicin . HCl

Topoisomerase inhibitor
BML-GR319-0005 5 mg 85.00 USD
BML-GR319-0025 25 mg 339.00 USD
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Replaces Prod. #: ALX-380-042

A broad spectrum antitumor agent. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Binds covalently to DNA. Inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1. Immunosuppressive. Antineoplastic. Induces apoptosis. Down regulates c-myc and c-jun in doxorubicin-sensitive cells.

Product Specification

Alternative Name:DXR . HCl, 14-Hydroxydaunomycin . HCl, Adriamycin . HCl
Formula:C27H29NO11 . HCl
MI:14: 3439
Purity:≥95% (HPLC)
Appearance:Red solid.
Solubility:Soluble in water.
Long Term Storage:Ambient
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
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Product Literature References

VEGF-A/Neuropilin 1 Pathway Confers Cancer Stemness via Activating Wnt/β-Catenin Axis in Breast Cancer Cells: L. Zhang, et al.; Cell. Physiol. Biochem. 44, 1251 (2017), Abstract; Full Text
Mcl-1 is a key regulator of the ovarian reserve: S. Omari, et al.; Cell. Death Dis. 6, e1755 (2015), Application(s): Cell Culture, Abstract; Full Text
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract; Full Text
The novel function of OCT4B isoform-265 in genotoxic stress: Y. Gao, et al.; Stem Cells 30, 665 (2012), Abstract; Full Text
Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis: K.B. Wallace; Cardiovasc. Toxicol. 7, 101 (2007), Review, Abstract;
Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to managemen: G. Takemura & H. Fujiwara; Prog. Cardiovasc. Dis. 49, 330 (2007), Review, Abstract;
The power and potential of doxorubicin-DNA adducts: S.M. Cutts, et al.; IUBMB Life 57, 73 (2005), Review, Abstract;
Characterization of Adriamycin-Induced G2 Arrest and Its Abrogation by Caffeine in FL-Amnion Cells with or without p53: Y. Minemoto, et al.; Exp. Cell Res. 262, 37 (2001), Abstract;
Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells: S. Gamen, et al.; Exp. Cell Res. 258, 223 (2000), Abstract;
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species: S. Kotamraju, et al.; J. Biol. Chem. 275, 33585 (2000), Abstract; Full Text
Enhancement of Fas-mediated apoptosis in renal cell carcinoma cells by adriamycin: X.X. Wu, et al.; Cancer Res. 60, 2912 (2000), Abstract;
Involvement of cyclin-dependent kinases in doxorubicin-induced apoptosis in human tumor cells: Y. Lu, et al.; Mol. Carcinog. 29, 1 (2000), Abstract;
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin: D.A. Gewirtz; Biochem. Pharmacol. 57, 727 (1999), Abstract;
Characterization of covalent adriamycin-DNA adducts: S.M. Zeman, et al.; Proc. Natl. Acad. Sci. USA 95, 11561 (1998), Abstract;
Doxorubicin-induced alterations of c-myc and c-jun gene expression in rat glioblastoma cells: role of c-jun in drug resistance and cell death: P. Pourquier, et al.; Biochem. Pharmacol. 55, 1963 (1998), Abstract;
Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor: O. Katoh, et al.; Cancer Res. 58, 5565 (1998), Abstract;
Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin: D.J. Taatjes, et al.; J. Med. Chem. 39, 4135 (1996), Abstract;
Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells: A. Skladanowski & J. Konopa; Biochem. Pharmacol. 46, 375 (1993), Abstract;

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