Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Doxorubicin . HCl

Topoisomerase inhibitor
 
BML-GR319-0005 5 mg 83.00 USD
 
BML-GR319-0025 25 mg 332.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-380-042

A broad spectrum antitumor agent. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Binds covalently to DNA. Inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1. Immunosuppressive. Antineoplastic. Induces apoptosis. Down regulates c-myc and c-jun in doxorubicin-sensitive cells.

Product Specification

Alternative Name:DXR . HCl, 14-Hydroxydaunomycin . HCl, Adriamycin . HCl
 
Formula:C27H29NO11 . HCl
 
MW:580.0
 
CAS:25316-40-9
 
MI:14: 3439
 
RTECS:QI9295900
 
Purity:≥95% (HPLC)
 
Appearance:Red solid.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
ALX-380-042
Please mouse over
ALX-380-042

Product Literature References

Mcl-1 is a key regulator of the ovarian reserve: S. Omari, et al.; Cell. Death Dis. 6, e1755 (2015), Application(s): Cell Culture, Abstract; Full Text
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract; Full Text
The novel function of OCT4B isoform-265 in genotoxic stress: Y. Gao, et al.; Stem Cells 30, 665 (2012), Abstract; Full Text
Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis: K.B. Wallace; Cardiovasc. Toxicol. 7, 101 (2007), Review, Abstract;
Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to managemen: G. Takemura & H. Fujiwara; Prog. Cardiovasc. Dis. 49, 330 (2007), Review, Abstract;
The power and potential of doxorubicin-DNA adducts: S.M. Cutts, et al.; IUBMB Life 57, 73 (2005), Review, Abstract;
Characterization of Adriamycin-Induced G2 Arrest and Its Abrogation by Caffeine in FL-Amnion Cells with or without p53: Y. Minemoto, et al.; Exp. Cell Res. 262, 37 (2001), Abstract;
Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells: S. Gamen, et al.; Exp. Cell Res. 258, 223 (2000), Abstract;
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species: S. Kotamraju, et al.; J. Biol. Chem. 275, 33585 (2000), Abstract; Full Text
Enhancement of Fas-mediated apoptosis in renal cell carcinoma cells by adriamycin: X.X. Wu, et al.; Cancer Res. 60, 2912 (2000), Abstract;
Involvement of cyclin-dependent kinases in doxorubicin-induced apoptosis in human tumor cells: Y. Lu, et al.; Mol. Carcinog. 29, 1 (2000), Abstract;
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin: D.A. Gewirtz; Biochem. Pharmacol. 57, 727 (1999), Abstract;
Characterization of covalent adriamycin-DNA adducts: S.M. Zeman, et al.; Proc. Natl. Acad. Sci. USA 95, 11561 (1998), Abstract;
Doxorubicin-induced alterations of c-myc and c-jun gene expression in rat glioblastoma cells: role of c-jun in drug resistance and cell death: P. Pourquier, et al.; Biochem. Pharmacol. 55, 1963 (1998), Abstract;
Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor: O. Katoh, et al.; Cancer Res. 58, 5565 (1998), Abstract;
Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin: D.J. Taatjes, et al.; J. Med. Chem. 39, 4135 (1996), Abstract;
Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells: A. Skladanowski & J. Konopa; Biochem. Pharmacol. 46, 375 (1993), Abstract;

Related Literature

Brochures
Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

Brochures
Stem Cells
Stem Cells
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,