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Coumermycin A1

DNA gyrase inhibitor
 
BML-GR317-0005 5 mg 149.00 USD
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Inhibits supercoiling activity of gyrase by binding to the gyrase B domain – but more importantly is a novel cell permeable dimerizing ligand for gyrase B fusion proteins. Has been used to dimerize a variety of signaling proteins such as Raf1, JAK2, Tyk and L-selectin.

Product Specification

Formula:C55H59N5O20
 
MW:1110.1
 
CAS:4434-05-3
 
Purity:≥97% (TLC)
 
Identity:Determined by IR.
 
Appearance:White to light yellow solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway: S. Kazemi, et al.; Mol. Biol. Cell 18, 3635 (2007), Abstract;
Activation and functional analysis of Janus kinase 2 in BA/F3 cells using the coumermycin/gyrase B system: M. G. Mohi et al.; Mol. Biol. Cell. 912, 3299 (1998), Abstract;
Conditional activation of Janus kinase (JAK) confers factor independence upon interleukin-3-dependent cells. Essential role of Ras in JAK-triggered mitogenesis: R. Mizuguchi et al.; J. Biol. Chem. 273, 32297 (1998), Abstract;
Regulation of L-selectin-mediated rolling through receptor dimerization: X. Li et al.; J. Exp. Med. 188, 1385 (1998), Abstract;
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin: F. T. Farrar et al.; Proteins 28, 41 (1997), Abstract;
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization: M. A. Farrar et al.; Nature 383, 178 (1996), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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