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10-Hydroxycamptothecin

Topoisomerase inhibitor
 
BML-GR316-0020 20 mg 81.00 USD
 
BML-GR316-0100 100 mg 332.00 USD
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A DNA topoisomerase I inhibitor that induces differentiation in HL-60 cells. It induces apoptosis in human breast cancer cell lines MCF-7 and MDA-MB-468.

Product Specification

Formula:C20H16N2O5
 
MW:364.4
 
CAS:64439-81-2
 
Purity:≥97%
 
Appearance:Pale yellow solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways: W. Liu, et al.; Int. J. Oncol. 12, 793 (1998), Abstract;
Differentiation induction of human promyelocytic leukemia cells by 10-hydroxycamptothecin, a DNA topoisomerase I inhibitor: Y.H. Ling, et al.; Differentiation 46, 135 (1991), Abstract;

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