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Ellipticine

Topoisomerase inhibitor
 
BML-GR315-0010 10 mg 102.00 USD
 
BML-GR315-0050 50 mg 422.00 USD
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A DNA-intercalating antitumor agent. Inhibits DNA topoisomerase II. Inhibits the phosphorylation of p53 in Lewis lung carcinoma cells and induces apoptosis. Inhibits cytochrome P-450-1A1.

Product Specification

Alternative Name:5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
 
Formula:C17H14N2
 
MW:246.3
 
CAS:519-23-3
 
Purity:≥98% (TLC)
 
Appearance:Bright yellow solid.
 
Solubility:Soluble in DMSO, DMF or ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Constitutive activation of the aromatic hydrocarbon receptor: C. Y. Chang, et al.; Mol. Cell Biol. 18, 525 (1998), Abstract; Full Text
Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism: M. Ohashi, et al.; Jpn. J. Cancer Res. 86, 819 (1995), Abstract;
Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy: S. J. Ammon-Froelich, et al.; J. Biol. Chem. 270, 14998 (1995), Abstract; Full Text

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