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Puromycin . 2HCl

Protein synthesis inhibitor
 
BML-GR312-0050 50 mg 59.00 USD
 
BML-GR312-0250 250 mg 223.00 USD
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Replaces Prod. #: ALX-380-028

Inhibits protein synthesis. Inhibits translation by causing premature release of nascent polypeptide. Induces apoptosis.

Product Specification

Alternative Name:3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine . 2HCl, 3'-(α-Amino-p-methoxy-hydrocinnamamido-3'-deoxy-N,N-dimethyl-adenosine . 2HCl
 
Formula:C22H29N7O5 . 2HCl
 
MW:544.4
 
CAS:58-58-2
 
MI:14: 7943
 
RTECS:AU7355000
 
Purity:≥98% (HPLC, TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from moisture.
 
BML-GR312 structure
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BML-GR312 structure

Product Literature References

Changes in O-GlcNAc homeostasis activate the p53 pathway in ovarian cancer cells: R.M. de Queiroz, et al.; J. Biol. Chem. 291, 18897 (2016), Application(s): Cell culture, human cell lines, Abstract;
Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1: G. Harada, et al.; J. Functional Foods 23, 444 (2016), Application(s): Cell culture,
Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation: C. Zhao, et al.; Oxid. Med. Cell. Longev. 2016, 2927131 (2016), Application(s): Retrovirus Production and Transduction, Abstract; Full Text
Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model: S. Meister, et al.; J. Cereb. Blood Flow Metab. 35, 1112 (2015), Application(s): Cell Culture, Abstract;
Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools: S. Balasubramanian, et al.; J. Biotechnol. 200, 61 (2015), Application(s): Cell Culture, Abstract;
Inhibition of puromycin-induced apoptosis in breast cancer cells by IGF-I occurs simultaneously with increased protein synthesis: G. Soderlund, et al.; Neoplasma 51, 1 (2004), Abstract;
Increased Apoptosis in Acute Puromycin Aminonucleoside Nephrosis: L. Fernandez, et al.; Exp. Nephrol. 9, 99 (2001), Abstract;
Puromycin Aminonucleoside Induces Glomerular Epithelial Cell Apoptosis: V. Sanwal, et al.; Exp. Mol. Pathol. 70, 54 (2001), Abstract;
Cell proliferation and apoptosis of the glomerular epithelial cells in rats with puromycin aminonucleoside nephrosis: H. Shiiki, et al.; Pathobiology 66, 221 (1998), Abstract;
Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization: D.B. Constam, et al.; J. Biol. Chem. 270, 26931 (1995), Abstract; Full Text
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow, et al.; Exp. Cell Res. 216, 149 (1995), Abstract;
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis: S.H. Kaufmann, et al.; Cancer Res. 53, 3976 (1993), Abstract;
Unexpected cytokinetic effects induced by puromycin include a G2- arrest, a metaphase-mitotic-arrest, and apoptosis: A.N. Davidoff & B.V. Mendelow; Leuk. Res. 16, 1077 (1992), Abstract;

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