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Mitomycin C

DNA synthesis inhibitor
 
BML-GR311-0002 2 mg 73.00 USD
 
BML-GR311-0010 10 mg 299.00 USD
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Replaces Prod. #: ALX-380-023

Antitumor antibiotic. DNA crosslinking and damaging agent. Inhibitor of DNA synthesis, nuclear division and cancer cells. DNA intercalating agent. Induces apoptosis in a variety of cells via a p53-dependent pathway.

Product Specification

Formula:C15H18N4O5
 
MW:334.3
 
CAS:50-07-7
 
MI:14: 6215
 
RTECS:CN0700000
 
Purity:≥95% (Assay)
 
Appearance:Blue-violet solid.
 
Solubility:Soluble in water (1mg/ml, warm), 100% ethanol (1mg/ml, warm), DMSO (15mg/ml) or methanol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions in water or ethanol are stable for up to 1 week at -20°C. Stock solutions in DMSO are stable for up to 1 month at -20°C.
 
Handling:Protect from light.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
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Product Literature References

Membrane-bound p35 Subunit of IL-12 on Tumor Cells is Functionally Equivalent to Membrane-bound Heterodimeric Single Chain IL-12 for Induction of Anti-tumor Immunity : H.J. Kim, et al.; Immune Netw. 16, 305 (2016), Application(s): Proliferation of ConA-activated splenocytes, Abstract; Full Text
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial associated necrosis in breast cancer: A. Bastian, et al.; J. Pharmacol. Exp. Ther. 353, 392 (2015), Application(s): Assay, Abstract; Full Text
Keratinocyte nicotinic acetylcholine receptor activation modulates early TLR2-mediated wound healing responses: M. Kishibe, et al.; Int. Immunopharmacol. 29, 63 (2015), Application(s): Cell Culture, Abstract;
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype: S. Duan, et al.0; Nat. Commun. 6, 10068 (2015), Application(s): Cell culture, MMC selectively killed PTEN-deficient NSCs, Abstract;
The novel function of OCT4B isoform-265 in genotoxic stress: Y. Gao, et al.; Stem Cells 30, 665 (2012), Abstract; Full Text
Activation of the S phase DNA damage checkpoint by mitomycin C: E. Mladenov, et al.; J. Cell. Physiol. 211, 468 (2007), Abstract;
Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin: M. Sasaki, et al.; Anticancer Res. 26, 3373 (2006), Abstract;
DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling: A.R. Tee & C.G. Proud; Oncogene 19, 3021 (2000), Abstract;
Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95- independent manner in human gastric adenocarcinoma cells: I.C. Park, et al.; Cancer Lett. 158, 125 (2000), Abstract;
Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis: C.T. Hsueh, et al.; Cancer Chemother. Pharmacol. 45, 389 (2000), Abstract;
Mitomycins: J. Verweij, et al.; Cancer Chemother. Biol. Response Modif. 18, 46 (1999), Abstract;
p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin: G.R. Merlo, et al.; J. Cell Biol. 128, 1185 (1995), Abstract;
Elevated DT-diaphorase activity and messenger RNA content in human non- small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl: A.M. Malkinson, et al.; Cancer Res. 52, 4752 (1992), Abstract;
Genetic evidence for an activator required for induction of pectin lyase in Erwinia carotovora subsp. carotovora by DNA-damaging agents: J.L. McEvoy, et al.; J. Bacteriol. 174, 5471 (1992), Abstract;
Polyoxyethylene-modified superoxide dismutase reduces side effects of adriamycin and mitomycin C: S. Kawasaki, et al.; J. Cancer Res. 83, 899 (1992), Abstract;
DNA sequence specificity of mitomycin cross-linking: S.P. Teng, et al.; Biochemistry 28, 3901 (1989), Abstract;
The chemistry of DNA modification by antitumor antibiotics: J.F. Fisher & P.A. Aristoff; Prog. Drug Res. 32, 411 (1988), Abstract;
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA: M. Tomasz, et al.; Science 235, 1204 (1987), Abstract;
Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p- hydroxyphenyl)mitomycin C: K. Ueda and T. Komano; Nucl. Acids Res. 12, 6673 (1984), Abstract;
Revised absolute configuration of mitomycin C. X-ray analysis of 1-N-(p-bromobenzoyl)mitomycin C: K. Shirahata & N. Hirayama; JACS 105, 7199 (1983),
Mitomycin C. Current Status and New Developments: S.K. Carter & S.T. Crooke ; Academic Press, New York (1979), (Book),
Mitomycin, a new antibiotic from Streptomyces. I: T. Hata, et al.; J. Antibiot. (Tokyo) 9, 141 (1956), Abstract;

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