Trichostatin A

HDAC inhibitor



BML-GR309-0001	1 mg	137.00 USD

BML-GR309-0005	5 mg	443.00 USD

Replaces Prod. #: ALX-380-068

Trichostatin A (TSA) is a potent and reversible inhibitor of histone deacetylases. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression (IC₅₀=73 nM) and displayed immunosuppressive activity in a mouse model.

Formula:	C₁₇H₂₂N₂O₃

MW:	302.4

Purity:	≥99% (HPLC)

Appearance:	solid

Formulation:	lyophilized

CAS:	58880-19-6

Source/Host:	Isolated from Streptomyces hygroscopicus

Solubility:	Soluble in DMSO, dimethyl formamide, acetonitrile, methanol or 100% ethanol

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Hazard:	HARMFUL. IRRITANT.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300: K.K. Bhakat & S. Mitra; J. Biol. Chem. 275, 34197 (34197), Abstract;

Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow: S. Snykers et al.; BMC Dev. Biol. 7, 24 (2007), Abstract;

Trichostatin A induces myocardial differentiation of monkey ES cells: M. Hosseinkhani et al.; Biochem. Biophys. Res. Commun. 356, 386 (2007), Abstract;

Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo: D.M. Vigushin; Clin. Cancer Res. 7, 971 (2001), Abstract;

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells: P.A. Marks et al.; J. Natl. Cancer Inst. 92, 1210 (2000), Abstract;

Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells: S.G. Gray et al.; Biochem. Biophys. Res. Commun. 245, 423 (1998), Abstract;

Retinoblastoma protein recruits histone deacetylase to repress transcription: A. Behm et al.; Nature 391, 597 (1998), Abstract;

A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells: S. Miucci et al.; PNAS 94, 11295 (1997), Abstract;

Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites: Y. Sowa et al.; Biochem. Biophys. Res. Commun. 241, 142 (1997), Abstract;

Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway: V. Medina et al.; Cancer Res. 57, 3697 (1997), Abstract;

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p: J. Taunton et al; Science Science, 408 (1996), Abstract;

Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase: I. Takahashi et al.; J. Antibiot. (Tokyo) 49, 453 (1996), Abstract;

Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation: C. Van Lint et al.; EMBO J. 15, 1112 (1996), Abstract;

Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function: M. Yoshida et al.; Bioessays 17, 423 (1995), Abstract;

Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines: Y. Hoshikawa et al.; Exp. Cell Res., 214, 189 (1994), Abstract;

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A: M. Yoshida et al.; J. Biol. Chem. 265, 17174 (1990), Abstract;

A new antifungal antibiotic, trichostatin: N. Tsuji et al.; J. Antibiot. (Tokyo) 29, 1 (1976), Abstract;

Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells: M. Futamura et al.; Oncogene 10, 1119 (1119), Abstract;