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β-Lapachone

Topoisomerase inhibitor
 
BML-GR308-0005 5 mg 75.00 USD
 
BML-GR308-0025 25 mg 318.00 USD
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Novel DNA topoisomerase I inhibitor. Unlike camptothecin, β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1.

Product Specification

Formula:C15H14O3
 
MW:242.4
 
CAS:4707-32-8
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Orange to brown solid.
 
Solubility:Soluble in DMSO (25mg/ml) or ethanol (20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity: J.J. Pink, et al.; J. Biol. Chem. 275, 5416 (2000), Abstract; Full Text
Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response: S.M. Planchon, et al.; Cancer Res. 55, 3706 (1995), Abstract; Full Text
beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin: C.J. Li, et al.; J. Biol. Chem. 268, 22463 (1993), Abstract; Full Text

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