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Etoposide

Topoisomerase inhibitor. p53 activator.
 
BML-GR307-0100 100 mg 88.00 USD
 
BML-GR307-0500 500 mg 349.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-209

Antitumor reagent. Topoisomerase II inhibitor. Induces apoptosis by FasL. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells.

Product Specification

Alternative Name:4-Desmethylepipodophyllotoxin 9-(4,6-O-ethylidene)-β-D-glucopyranoside, VP-16-213
 
Formula:C29H32O13
 
MW:588.6
 
Source:Semisynthetic derivative of podophyllotoxin.
 
CAS:33419-42-0
 
MI:14: 3886
 
RTECS:KC0190000
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO, dimethyl formamide, ethyl ether or chloroform:methanol (1:1); slightly soluble in methanol or acetone; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
 
Handling:Protect from light and moisture.
 
ALX-270-209
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ALX-270-209

Product Literature References

Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II: M. Liu, et al.; J. Biol. Chem. 290, 14418 (2015), Application(s): Cell Culture, Abstract; Full Text
The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death: F. J. Bock, et al.; Sci. Rep. 5, 11268 (2015), Application(s): Cell Culture, Abstract; Full Text
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases: M. Rebsamen, et al.; Cell Death Differ. 15, 1804 (2008), Abstract;
Etoposide, topoisomerase II and cancer: E.L. Baldwin & N. Osheroff; Curr. Med. Chem. Anticancer Agents 5, 363 (2005), Review, Abstract;
Etoposide: discovery and medicinal chemistry: P. Meresse, et al.; Curr. Med. Chem. 11, 2443 (2004), Review, Abstract;
Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin- dependent enzymes: M. Aoyama, et al.; Biochem. Pharmacol. 61, 49 (2001), Abstract;
Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis: C.A. Johnson, et al.; J. Biol. Chem. 276, 4539 (2001), Abstract; Full Text
In vitro topo II-DNA complex accumulation and cytotoxicity of etoposide in leukaemic cells from patients with acute myelogenous and chronic lymphocytic leukaemia: Y. Wang, et al.; Leuk. Res. 25, 133 (2001), Abstract;
A systematic review of the role of etoposide and cisplatin in the chemotherapy of small cell lung cancer with methodology assessment and meta-analysis: C. Mascaux, et al.; Lung Cancer 30, 23 (2000), Abstract;
Distinct pathways for stimulation of cytochrome c release by etoposide: J.D. Robertson, et al.; J. Biol. Chem. 275, 32438 (2000), Abstract; Full Text
Early caspase activation in leukemic cells subject to etoposide-induced G2-M arrest: evidence of commitment to apoptosis rather than mitotic cell death: R.J. Sleiman & B.W. Stewart; Clin. Cancer Res. 6, 3756 (2000), Abstract; Full Text
Etoposide-induced apoptosis is not associated with the fas pathway in acute myeloblastic leukemia cells: T. Siitonen, et al.; Leuk. Res. 24, 281 (2000), Abstract;
Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells: M. Sawada, et al.; Cell Death Differ. 7, 761 (2000), Abstract;
Etoposide sensitivity of human prostatic cancer cell lines PC-3, DU 145 and LNCaP: M. Salido, et al.; Histol. Histopathol. 14, 125 (1999), Abstract;
Etoposide: four decades of development of a topoisomerase II inhibitor: K.R. Hande; Eur. J. Cancer 34, 1514 (1998), Abstract;
Etoposide: twenty years later: J.D. Hainsworth & F.A. Greco; Ann. Oncol. 6, 325 (1995), Abstract;
Review of current clinical experience with prolonged (oral) etoposide in cancer treatment: R.S. de Jong, et al.; Anticancer Res. 15, 2319 (1995), Abstract;
Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle: H.O. Fearnhead, et al.; Biochem. Pharmacol. 48, 1073 (1994), Abstract;
The podophyllotoxin derivatives VP16-213 and VM26: B.F. Issell; Cancer Chemother. Pharmacol. 7, 73 (1982), Abstract;

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