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Mithramycin A

Transcription inhibitor
 
BML-GR305-0001 1 mg 57.00 USD
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Replaces Prod. #: ALX-380-097

Mithramycin noncovalently interacts with G-C-rich duplex DNA in the presence of Mg2+ or Zn2+. It induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression. It selectively inhibits collagen-1 gene expression in human fibroblasts.

Product Specification

Alternative Name:Plicamycin
 
Formula:C52H76O24
 
MW:1085.1
 
Source:Isolated from Streptomyces argillaceus
 
CAS:18378-89-7
 
MI:14: 7536
 
Purity:≥95% (HPLC, TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in phosphate buffered saline (1mg/ml), 100% ethanol, DMSO or methanol
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells: E. Im, et al.; Life Sci. (2017), Abstract;
Mithramycin A activates Fas death pathway in leukemic cell lines: I. Leroy, et al.; Apoptosis 11, 113 (2006), Abstract;
Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression: S.Y. Ahn, et al.; Am. J. Pathol. 164, 1663 (2004), Abstract;
Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3: M.A. Mir, et al.; Bioorg. Med. Chem. 11, 2791 (2003), Abstract;
Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast: M.C. Nehls, et al.; J. Clin. Invest. 92, 2916 (1993), Abstract;
Interaction of mithramycin with DNA. Evidence that mithramycin binds to DNA as a dimer in a right-handed screw conformation: C. Demicheli, et al.; Eur. J. Biochem. 198, 333 (1991), Abstract;
Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene: R. Ray, et al.; Am. J. Med. Sci. 300, 203 (1990), Abstract;
Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea: C.A. Koller & D.M. Miller; N. Engl. J. Med. 315, 1433 (1986), Abstract;
Chromomycin A3, mithramycin, and olivomycin: antitumor antibiotics of related structure: M. Slavik & S.K. Carter; Adv. Pharmacol. Chemother. 12, 1 (1975), Abstract;
Aureolic acid group of anti-tumour antibiotics: Y.U. Berlin, et al.; Nature 218, 193 (1968), Abstract;

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