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Chromomycin A3

Transcription inhibitor
 
BML-GR302-0010 10 mg 228.00 USD
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Replaces Prod. #: ALX-380-055

Chromomycin A3 is a GC-specific DNA ligand which inhibits transcription. It may be used as a fluorescent DNA stain. Antibiotic. Cell permeable fluorescent dye that cann be used with Bisbenzimide H33258 to distinguish chromosomes by their total DNA concentration and their DNA base composition. Does not intercalate. Ex(max): 445nm;  Em(max): 575nm

Product Specification

Formula:C57H82O26
 
MW:1183.3
 
Source:Isolated from Streptomyces griseus
 
CAS:7059-24-7
 
Purity:≥98% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in 100% ethanol, DMSO or ethyl acetate (10mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Protect from light.
 
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Product Literature References

Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells: S. Wong, et al.; Biochem. Pharmacol. 47, 827 (1994), Abstract;
Selective accumulation of diamidino yellow and chromomycin A3 by retinal glial cells: C.-J. Jeon & R.H. Masland; J. Histochem. Cytochem. 41, 1651 (1993), Abstract;
Specific staining of DNA with the fluorescent antibiotics, mithramycin, chromomycin, and olivomycin: H.A. Crissman & R.A. Tobey; Methods. Cell Biol. 33, 97 (1990), Abstract;
Chromomycin A3 and its derivatives: K. Mizuno ; J. Antibiot. 16, 22 (1963),

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