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Actinomycin D

Intercalating transcription inhibitor
 
BML-GR300-0005 5 mg 68.00 USD
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Replaces Prod. #: ALX-380-009

An intercalating transcription inhibitor and antineoplastic antibiotic. Inhibits transcription by binding to DNA at dG residues. Induces apoptosis in many cell lines, but suppresses in PC12 cells induced by topoisomrease II inhibitor etopside. Used at 5-10µg/ml in cell culture for haltiong transcription. The product is not sterile.

Product Specification

Formula:C62H86N12O16
 
MW:1255.5
 
Source:Isolated from Streptomyces parvulus.
 
CAS:50-76-0
 
Purity:≥98% (TLC)
 
Appearance:Red-orange crystalline solid.
 
Solubility:Soluble in DMSO (>20mg/ml), 100% ethanol (1mg/ml) or methanol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Sensitive to strong acids and bases. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Protect from light. Hygroscopic.
 
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Product Literature References

PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract; Full Text
The Wnt target Peter Pan defines a novel p53-independent nucleolar stress response pathway: A.S. Pfister, et al.; J. Biol. Chem. 290, 10905 (2015), Application(s): Cell Culture, Abstract; Full Text
Actinomycin D enhances TRAIL-induced caspase-dependent and -independent apoptosis in SH-SY5Y neuroblastoma cells: M. J. Wang et al.; Neurosci. Res. 59, 40 (2007), Abstract;
Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes: I. Kalousek et al.; Anticancer Drugs 18, 763 (2007), Abstract;
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II: H.E. Mischo et al.; J. Biol. Chem. 280, 9586 (2005), Abstract;
Actinomycin D inhibiting K562 cell apoptosis elicited by salvicine but not decreasing its cytotoxicity: C. Qing et al.; Acta Pharmacol. Sin. 24, 415 (2003), Abstract;
Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells: J. Kleeff et al.; Int. J. Cancer 86, 399 (2000), Abstract;
Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice: M. Akahori et al.; J. Surg. Res. 85, 286 (1999), Abstract;
Tumor necrosis factor-alpha plus actinomycin D induced apoptosis lf L929 cells is prevented by nitric oxide: S. Hakoda et al.; Surg. Today 29, 1059 (1999),
Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line: S. Verhaegen et al.; Biochem. Pharmacol. 50, 1021 (1995), Abstract;
Influence of DNA base sequence on the binding energetics of actinomycin D: S.A. Bailey et al.; Biochemistry 32, 5881 (1993), Abstract;
Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle: J.M. Glynn et al.; Biochem. Soc. Trans. 20, 84S (1992), Abstract;
Studies on 2-Aziridinecarboxylic Acid. VIII. Total Synthesis of Actinomycin D and Its Serine Analogue via Ring-opening Reaction of 1-Benzyloxycarbonyl-2-aziridinecarboxylic Acid Moiety: K. Nakajima et al.; Bull. Chem. Soc. Jpn. 55, 3237 (1982), Abstract;

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