Selective estrogen receptor ERβ agonist displaying 68-fold greater selectivity over ERα (EC50 = 2 and 155nM, respectively). It stimulates galanin expression in GnRH neurons and displays anxiolytic/antidepressant activity in various in vivo rodent models (administration to mice at 30mg/kg s.c.).
Product Details
| Alternative Name: | 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol |
| |
| Formula: | C13H8BrNO3 |
| |
| MW: | 306.1 |
| |
| CAS: | 440122-66-7 |
| |
| Purity: | ≥98% (TLC) |
| |
| Appearance: | Off-white solid. |
| |
| Solubility: | Soluble in DMSO (12mg/ml) or 100% ethanol (2.5mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | Ambient |
| |
| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at-20°C for up to 3 months. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress: M.J. Weiser, et al.; Endocrinology
150, 1817 (2009),
Abstract;
WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent: Z.A. Hughes, et al.; Neuropharmacology
54, 1136 (2008),
Abstract;
Estrogen and estrogen receptor-{beta} (ER{beta})-selective ligands induce galanin expression within gonadotropin hormone-releasing hormone-immunoreactive neurons in the female rat brain: I. Merchenthaler, et al.; Endocrinology
146, 2760 (2005),
Abstract;
Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands: M.S. Malamas, et al.; J. Med. Chem.
47, 5021 (2004),
Abstract;
