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WAY-200070

Estrogen receptor ligand
 
BML-GR247-0010 10 mg 119.00 USD
 
BML-GR247-0050 50 mg 433.00 USD
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Selective estrogen receptor ERβ agonist displaying 68-fold greater selectivity over ERα (EC50 = 2 and 155nM, respectively). It stimulates galanin expression in GnRH neurons and displays anxiolytic/antidepressant activity in various in vivo rodent models (administration to mice at 30mg/kg s.c.).

Product Specification

Alternative Name:7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
 
Formula:C13H8BrNO3
 
MW:306.1
 
CAS:440122-66-7
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (12mg/ml) or 100% ethanol (2.5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year.  Store solutions at-20°C for up to 3 months.
 
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Product Literature References

Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress: M.J. Weiser, et al.; Endocrinology 150, 1817 (2009), Abstract;
WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent: Z.A. Hughes, et al.; Neuropharmacology 54, 1136 (2008), Abstract;
Estrogen and estrogen receptor-{beta} (ER{beta})-selective ligands induce galanin expression within gonadotropin hormone-releasing hormone-immunoreactive neurons in the female rat brain: I. Merchenthaler, et al.; Endocrinology 146, 2760 (2005), Abstract;
Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands: M.S. Malamas, et al.; J. Med. Chem. 47, 5021 (2004), Abstract;

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