Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

6-ECDCA

FXR ligand
 
BML-GR246-0005 5 mg 95.00 USD
 
BML-GR246-0025 25 mg 385.00 USD
Do you need bulk/larger quantities?
 
A novel derivative of cholic acid which acts as a potent and selective FXR agonist (EC50= 99nM) displaying anticholeretic activity in an in vivo rat model of cholestasis. It not only inhibits vascular smooth muscle cell inflammation and migration but also promotes adipocyte differentiation and regulates adipose cell function in vivo.

Product Specification

Alternative Name:6-Ethylchenodeoxycholic acid, 3α,7α-Dihydroxy-6α-ethyl-5β-cholan-24-oic acid, Obeticholic acid
 
Formula:C26H44O4
 
MW:420.6
 
CAS:459789-99-2
 
Purity:≥97% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (35mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
bml-gr246
Please mouse over
bml-gr246

Product Literature References

A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis: C. Ejima, et al.; Physiol. Rep. 4, 21 (2016), Abstract; Full Text
Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration: Y.T. Li, et al.; Arterioscler. Thromb. Vasc. Biol. 27, 2606 (2007), Abstract;
The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo: G. Rizzo, et al.; Mol. Pharmacol. 70, 1164 (2006), Abstract;
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis: S. Fiorucci, et al.; J. Pharmacol. Exp. Ther. 313, 604 (2005), Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
FXR
By biological activity:
FXR Ligand
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,