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TCPOBOP

Constitutive androstane receptor (CAR) activator
 
BML-GR245-0005 5 mg 41.00 USD
 
BML-GR245-0025 25 mg 142.00 USD
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TCPOBOP is an activator of the mouse constitutive androstane receptor (CAR) and a potent inducer of cytochrome P450 monoxygenase activity. Has been shown to have a potent tumor-promoting activity and hepatocarcinogenic effects in mice but not in rats.

Product Specification

Alternative Name:1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene
 
Formula:C16H8Cl4N2O2
 
MW:402.1
 
Source:Synthetic.
 
CAS:76150-91-9
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-GR245 structure
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BML-GR245 structure

Product Literature References

Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport: J. S. Petrick & C. D. Klaassen; Drug Metab. Dispos. 35, 1806 (2007), Abstract; Full Text
Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins: E. S. Baskin-Bey, et al.; Hepatology 44, 252 (2006), Abstract;
Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine: B. A. Diwan, et al.; Carcinogenesis 13, 1893 (1992), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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