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3-Methylcholanthrene

Ah receptor ligand
 
BML-GR239-0010 10 mg 66.00 USD
 
BML-GR239-0050 50 mg 270.00 USD
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Aryl hydrocarbon receptor (AhR) agonist. Inhibits osteoclast formation by inhibiting the expression of receptor activator of NF-κB receptor ligand (RANKL). Suppresses growth factor and JAK-2 expression in mice.

Product Specification

Formula:C21H16
 
MW:268.4
 
CAS:56-49-5
 
Purity:≥97% (TLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:Yellow solid.
 
Solubility:Soluble in chloroform or ethyl acetate.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice: M. Nukaya, et al.; FEBS Lett. 558, 96 (2004), Abstract;
Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells: J. Yamamoto, et al.; Life Sci. 74, 1039 (2004), Abstract;
Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for arylhydrocarbon receptor: suppression of osteoclast differentiation factor in osteogenic cells: M. Naruse, et al.; Biochem. Pharmacol. 67, 119 (2004), Abstract;

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