Replaces Prod. #: ALX-270-356
Potent, selective and irreversible PPARγ antagonist. Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1µM. Much more potent antagonist than BADGE (Prod. No. ALX-270-353). Can be used to antagonize the effects of PPARγ agonists in a variety of cell types.
Product Details
| Alternative Name: | 2-Chloro-5-nitrobenzanilide |
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| Formula: | C13H9N2O3Cl |
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| MW: | 276.7 |
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| CAS: | 22978-25-2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| MeltingPoint: | 155-157°C |
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| Solubility: | Soluble in DMSO (50mg/ml), 100% ethanol (10mg/ml) or dimethyl formamide. Insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Halogenated bisphenol a analogues induce PPARγ-independent toxicity within human hepatocellular carcinoma cells: V. Cheng & D.C. Volz; Curr. Res. Toxicol.
3, 100079 (2022),
Abstract;
Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation: I. Khuja, et al.; Int. J. Mol. Sci.
20, 668 (2019),
Application(s): used to examine CBDs effect on proliferation of CD3 activated murine splenocytes,
Abstract;
Full Text
Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes: Q. Mu, et al.; Biochem. Biophys. Res. Commun.
291, 30581 (2015),
Application(s): Antagonize the effects of PPARγ agonists,
Abstract;
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications: T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab.
90, 3534 (2005),
Abstract;
Full Text
PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes: A.D. Roth, et al.; J. Neurosci. Res.
72, 425 (2003),
Abstract;
Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells: M. Fu, et al.; BBRC
294, 597 (2002),
Abstract;
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662: L.M. Leesnitzer, et al.; Biochemistry
41, 6640 (2002),
Abstract;
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1: A.C. Bendixen, et al.; PNAS
98, 2443 (2001),
Abstract;
Full Text
Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3: M. Fu, et al.; J. Biol. Chem.
276, 45888 (2001),
Abstract;
