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GW-9662

PPAR ligand
 
BML-GR234-0010 10 mg 83.00 USD
 
BML-GR234-0050 50 mg 336.00 USD
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Replaces Prod. #: ALX-270-356

Potent, selective and irreversible PPARγ antagonist. Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1µM. Much more potent antagonist than BADGE (Prod. No. ALX-270-353). Can be used to antagonize the effects of PPARγ agonists in a variety of cell types.

Product Specification

Alternative Name:2-Chloro-5-nitrobenzanilide
 
Formula:C13H9N2O3Cl
 
MW:276.7
 
CAS:22978-25-2
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
MeltingPoint:155-157°C
 
Solubility:Soluble in DMSO (50mg/ml), 100% ethanol (10mg/ml) or dimethyl formamide. Insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
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Product Literature References

Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes: Q. Mu, et al.; Biochem. Biophys. Res. Commun. 291, 30581 (2015), Application(s): Antagonize the effects of PPARγ agonists, Abstract;
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications: T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab. 90, 3534 (2005), Abstract; Full Text
PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes: A.D. Roth, et al.; J. Neurosci. Res. 72, 425 (2003), Abstract;
Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells: M. Fu, et al.; BBRC 294, 597 (2002), Abstract;
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662: L.M. Leesnitzer, et al.; Biochemistry 41, 6640 (2002), Abstract;
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1: A.C. Bendixen, et al.; PNAS 98, 2443 (2001), Abstract; Full Text
Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3: M. Fu, et al.; J. Biol. Chem. 276, 45888 (2001), Abstract;

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