Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

CITCO

Constitutive androstane receptor ligand
 
BML-GR233-0005 5 mg 72.00 USD
 
BML-GR233-0025 25 mg 278.00 USD
Do you need bulk/larger quantities?
 
CITCO is a novel potent and selective agonist for the human orphan nuclear receptor CAR (constitutive androstane receptor). CITCO displayed an EC50 of 49 nM in a CAR FRET assay and showed 50-fold selectivity for CAR over PXR. CITCO displayed no activity against a panel of 15 other nuclear receptors at a concentration of 10 µM. In hepatocytes CITCO induced CAR nuclear translocation and induced the CAR target gene CYP2B6.

Product Specification

Alternative Name:6-(4-Chlorophenyl)imidazo[2,1-b] [1,3]thiazole-5-carbaldehyde O-3,4-dichlorobenzyl) oxime
 
Formula:C19H12Cl3N3OS
 
MW:436.7
 
CAS:338404-52-7
 
Appearance:Pale orange solid.
 
Solubility:Soluble in DMF (25mg/ml) or DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
bml-gr233
Please mouse over
bml-gr233

Product Literature References

Activating and Inhibitory Functions of WNT/β-catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells: M. Thomas, et al.; Mol. Pharmacol. (2015), Application(s): Cell Culture, Abstract; Full Text
Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: CYP Expression and Induction by Nuclear Receptor Agonists: A. Braeuning, et al.; Drug Metab. Dispos. 43, 1781 (2015), Application(s): Cell Culture, Abstract; Full Text
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes: J.M. Maglich, et al.; J. Biol. Chem. 278, 17277 (2003), Abstract; Full Text

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Constitutive androstane receptor
By biological activity:
Constitutive androstane receptor Ligand
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,