Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer’s disease and mild cognitive impairment.
Product Details
| Formula: | C27H46O2 |
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| MW: | 402.7 |
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| CAS: | 474-73-7 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| MeltingPoint: | 177-180°C |
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| Solubility: | Soluble in ethanol (10mg/ml) or DMSO (10mg/ml - requires warming to ~40°C). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation: J.M. Carthy, et al.; Sci. Rep.
6, 29868 (2016),
Application(s): Screening of chemical compounds with HaCaT cells,
Abstract;
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24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8: D.K. Vo, et al.; Steroids
99, 230 (2015),
Application(s): Cell Culture,
Abstract;
Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?: V. Leoni, et al.; Neurosci. Lett.
397, 83 (2006),
Abstract;
Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls: P. Schonknecht, et al.; Neurosci. Lett.
324, 83 (2002),
Abstract;
Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta: H. Kolsch, et al.; J. Neural Transm.
108, 475 (2001),
Abstract;
Nuclear receptors and lipid physiology: opening the X-files: A. Chawla, et al.; Science
294, 1866 (2001),
Abstract;
The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells: H. Kolsch, et al.; Brain Res.
818, 171 (1999),
Abstract;
Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation: D. Lutjohann, et al.; PNAS U.S.A.
93, 9799 (1996),
Abstract;
