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24(S)-Hydroxycholesterol

LXR ligand
 
BML-GR230-0001 1 mg 104.00 USD
 
BML-GR230-0005 5 mg 420.00 USD
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Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer’s disease and mild cognitive impairment.

Product Specification

Formula:C27H46O2
 
MW:402.7
 
CAS:474-73-7
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
MeltingPoint:177-180°C
 
Solubility:Soluble in ethanol (10mg/ml) or DMSO (10mg/ml - requires warming to ~40°C).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation: J.M. Carthy, et al.; Sci. Rep. 6, 29868 (2016), Application(s): Screening of chemical compounds with HaCaT cells, Abstract; Full Text
24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8: D.K. Vo, et al.; Steroids 99, 230 (2015), Application(s): Cell Culture, Abstract;
Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?: V. Leoni, et al.; Neurosci. Lett. 397, 83 (2006), Abstract;
Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls: P. Schonknecht, et al.; Neurosci. Lett. 324, 83 (2002), Abstract;
Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta: H. Kolsch, et al.; J. Neural Transm. 108, 475 (2001), Abstract;
Nuclear receptors and lipid physiology: opening the X-files: A. Chawla, et al.; Science 294, 1866 (2001), Abstract;
The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells: H. Kolsch, et al.; Brain Res. 818, 171 (1999), Abstract;
Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation: D. Lutjohann, et al.; PNAS U.S.A. 93, 9799 (1996), Abstract;

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