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T0070907

PPAR ligand
 
BML-GR212-0010 10 mg 93.00 USD
 
BML-GR212-0050 50 mg 357.00 USD
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Potent and selective PPARγ antagonist. T0070907 blocks PPARγ function in both cell-based reporter gene and adipocyte differentiation assays. It inhibits growth and survival of hepatocellular carcinoma cells and squamous cell carcinoma cell lines by interfering with cell adhesion "anoikis".

Product Specification

Alternative Name:2-Chloro-5-nitro-N-4-pyridinylbenzamide
 
Formula:C12H8ClN3O3
 
MW:277.7
 
CAS:313516-66-4
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (>25 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year.  Store solutions at-20°C for up to 3 months.
 
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Product Literature References

Critical role of peroxisome proliferator-activated receptor gamma on anoikis and invasion of squamous cell carcinoma: T. Masuda, et al.; Clin. Cancer Res. 11, 4012 (2005), Abstract; Full Text
Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells: K. L. Schaefer, et al.; Cancer Res. 65, 2251 (2005), Abstract; Full Text
PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis: H. P. Raikwar, et al.; J. Neuroimmunol. 167, 99 (2005), Abstract;
T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities: G. Lee, et al.; J. Biol. Chem. 277, 19649 (2002), Abstract; Full Text

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