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Ciglitazone

PPAR ligand
 
BML-GR205-0005 5 mg 108.00 USD
 
BML-GR205-0025 25 mg 445.00 USD
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Replaces Prod. #: ALX-270-255

Ciglitazone is a thiazolidinedione type of antihyperglycemic agent. It displays antihyperglycemic activity in genetically obese C57 Bl/6 ob/ob mice and is a selective PPARγ agonist (EC50=3 µM). Inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells.

Product Specification

Formula:C18H23NO3S
 
MW:333.5
 
Source:Synthetic.
 
CAS:74772-77-3
 
RTECS:XJ5813700
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Tan solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
 
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Product Literature References

The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses: R.B. Clark, et al.; J. Immunol. 164, 1364 (2000), Abstract;
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999), Abstract;
Thiazolidinediones--the new insulin enhancers: R.J. Jha; Clin. Exp. Hypertens. 21, 157 (1999), Abstract;
Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells: B. Lohrke, et al.; J. Endocrinol. 159, 429 (1998), Abstract;
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996), Abstract;
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994), Abstract;

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