Replaces Prod. #: ALX-270-255
Ciglitazone is a thiazolidinedione type of antihyperglycemic agent. It displays antihyperglycemic activity in genetically obese C57 Bl/6 ob/ob mice and is a selective PPARγ agonist (EC50=3 µM). Inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells.
Product Details
| Formula: | C18H23NO3S |
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| MW: | 333.5 |
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| Source: | Synthetic. |
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| CAS: | 74772-77-3 |
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| RTECS: | XJ5813700 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses: R.B. Clark, et al.; J. Immunol.
164, 1364 (2000),
Abstract;
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem.
274, 9116 (1999),
Abstract;
Thiazolidinediones--the new insulin enhancers: R.J. Jha; Clin. Exp. Hypertens.
21, 157 (1999),
Abstract;
Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells: B. Lohrke, et al.; J. Endocrinol.
159, 429 (1998),
Abstract;
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem.
39, 665 (1996),
Abstract;
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem.
37, 3977 (1994),
Abstract;
