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Adapalene

Retinoic acid receptor ligand
 
BML-GR111-0020 20 mg 110.00 USD
 
BML-GR111-0100 100 mg 412.00 USD
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Adapalene is a stable analog of retinoic acid and acts selectively as an agonist at RARβ and RARγ. It inhibits proliferation and induces apoptosis in colorectal cancer cells. Its unique pharmacological properties make it superior to other retinoids for the treatment of acne.

Product Specification

Alternative Name:6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid
 
Formula:C19H34O3
 
MW:412.5
 
CAS:106685-40-9
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (3 mg/mL) or DMF (6 mg/mL).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year.  Store solutions at-20°C for up to 3 months.
 
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Product Literature References

The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro: M. Ocker, et al.; Int. J. Cancer 107, 453 (2003), Abstract;
Adapalene: an update on newer comparative studies between the various retinoids: L. E. Milikan, et al.; Int. J. Dermatoil. 39, 784 (2000), Abstract;
Pharmacology of adapalene: S. Michel, et al.; Br. J. Dermatol. 139, 52 (1998), Abstract;

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