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Ro 41-5253

Retinoic acid receptor ligand
 
BML-GR110-0005 5 mg 86.00 USD
 
BML-GR110-0025 25 mg 344.00 USD
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A selective RARα antagonist (concentration required to inhibit 50% of specific retinoic acid binding: RARα, 60 nM; RARß, 2400 nM; RARτ, 3300 nM). Counteracts the effects of retinoic acid on HL-60 cell differentiation, B-lymphocyte polyclonal activation and in a RARα transactivation assay. Ro 41-5253 suppresses retinoic acid-induced connexin 43 protein expression in 10T1/2 cells.

Product Specification

Formula:C28H36O5S
 
MW:484.7
 
CAS:144092-31-9
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (50mg/ml) or 100% ethanol (15mg/ml, warm).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Detection of retinoic acid receptor antagonist contamination in the aquatic environment of the Kinki region of Japan: D. Inoue, et al.; Water Res. 103, 58 (2016), Application(s): RAR antagonistic activity assay, Abstract;
Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn's disease: N.E. McCarthy, et al.; J. Clin. Invest. 125, 3215 (2015), Application(s): Cell Culture, Abstract; Full Text
Cancer prevention by retinoids and carotenoids: independent action on a common target: J. S. Bertram; Biochim. Biophys. Acta. 1740, 170 (2005), Abstract;
Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping: S. Keidel et al.; Mol. Cell. Biol. 14, 287 (1994), Abstract;

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