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AM-580

Retinoic acid receptor ligand
 
BML-GR104-0005 5 mg 95.00 USD
 
BML-GR104-0025 25 mg 397.00 USD
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Retinoic acid analog which acts as a selective RARα agonist with no affinity for RXRs. Induces differentiation in leukemia cell lines and inhibits angiogenesis in chick embryos.

Product Specification

Formula:C22H25NO3
 
MW:351.4
 
CAS:102121-60-8
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (25mg/ml) and ethanol (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells: M. Gianni, et al.; Blood 87, 1520 (1996), Abstract;
Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs: S.C. Brooks, et al.; Blood 87, 227 (1996), Abstract;
Three novel synthetic retinoids, Re 80, Am 580 and Am 80, all exhibit anti-angiogenic activity in vivo: T. Oikawa, et al.; Eur. J. Pharmacol. 249, 113 (1993), Abstract;
Selective synthetic ligands for human nuclear retinoic acid receptors: B. Martin, et al.; Skin Pharmacol. 5, 57 (1992), Abstract;

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