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9-cis-Retinoic acid

Retinoid X receptor ligand
 
BML-GR101-0005 5 mg 146.00 USD
 
BML-GR101-0025 25 mg 538.00 USD
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A high affinity ligand for the retinoid X receptor (RXR). Destabilizes VDR-RXR heterodimer-DNA complex.

Product Specification

Alternative Name:Alitretinoin
 
Formula:C20H28O2
 
MW:300.4
 
CAS:5300-03-8
 
Purity:≥98% (HPLC)
 
Appearance:Light yellow to orange crystalline powder.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Store tightly sealed in dark. Protect from light.
 
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Product Literature References

Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers: B. Cheskis & L. P. Freedman; Mol. Cell. Biol. 14, 3329 (1994), Abstract; Full Text
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids: G. Allenby, et al.; Proc. Natl. Acad. Sci. USA 90, 30 (1993), Abstract; Full Text
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor: R. A. Heyman, et al.; Cell 68, 397 (1992), Abstract;
9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha: A. A. Levin, et al.; Nature 355, 359 (1992), Abstract;

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