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Isotetrandrine

Phospholipase inhibitor
 
BML-G520-0001 1 mg 66.00 USD
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Replaces Prod. #: ALX-350-035

Isotetrandrine is a biscoclaurine alkaloid which inhibits G-protein mediated activation of phospholipase A2 (PLA2) but not phospholipase C (PLC) or D (PLD). Cell permeable.

Product Specification

Alternative Name:Berbamine methyl ether, 6,6',7,12-Tetramethoxy-2,2'-dimethyl-berbaman
 
Formula:C38H42N2O6
 
MW:622.7
 
CAS:477-57-6
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (20mg/ml) or ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Inhibition of membrane tubule formation and trafficking by isotetrandrine, an antagonist of G-protein-regulated phospholipase A2 enzymes: D. Chan, et al.; Mol. Biol. Cell. 15, 1871 (2004), Abstract;
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol. 44, 45 (1992), Abstract;
Tetrandrine and isotetrandrine, two bisbenzyltetrahydroisoquinoline alkaloids from Menispermaceae, with rat uterine smooth muscle relaxant activity: P. D'Ocón, et al.; J. Pharm. Pharmacol. 44, 579 (1992), Application(s): inhibition of uterine contraction, Abstract;
Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets: T. Hashizume, et al.; Biochem. Pharmacol. 41, 419 (1991), Abstract;
Total syntheses of optically active natural isotetrandrine, phaeanthine and tetrandrine: Y. Inubushi, et al.; Tetrahedron Lett. 30, 3399 (1968), Abstract;

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