Replaces Prod. #: ALX-165-002
A G protein antagonist which selectively inhibits the activation of Gq by M1 muscarinic cholinergic receptors (mAChR). Not effective in inhibiting M2 mAChR-promoted GTP hydrolysis by Gi. Inhibition is reversible and competitive with respect to receptor binding to G proteins. Also inhibits activation by cholecystokinin receptor in pancreatic acini at 10µM.
Product Details
Alternative Name: | G-protein antagonist 2A |
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Sequence: | H-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2 |
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Formula: | C79H105N21O13S |
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MW: | 1588.9 |
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Formulation: | Lyophilized. |
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Purity: | ≥99% (HPLC) |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in water (25mg/ml). |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding: H. Mukai et al; J. Biol. Chem.
267, 16237 (1992),
Abstract;
Full Text
Biological evaluation of substance P antagonists: K. Folkers et al.; Br. J. Pharmacol.
83, 449 (1984),
Abstract;