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GP antagonist-2A

G protein antagonist
 
BML-G515-0001 1 mg 121.00 USD
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Replaces Prod. #: ALX-165-002

A G protein antagonist which selectively inhibits the activation of Gq by M1 muscarinic cholinergic receptors (mAChR). Not effective in inhibiting M2 mAChR-promoted GTP hydrolysis by Gi. Inhibition is reversible and competitive with respect to receptor binding to G proteins. Also inhibits activation by cholecystokinin receptor in pancreatic acini at 10µM.

Product Specification

Alternative Name:G-protein antagonist 2A
 
Sequence:H-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2
 
Formula:C79H105N21O13S
 
MW:1588.9
 
Formulation:Lyophilized.
 
Purity:≥99% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding: H. Mukai et al; J. Biol. Chem. 267, 16237 (1992), Abstract; Full Text
Biological evaluation of substance P antagonists: K. Folkers et al.; Br. J. Pharmacol. 83, 449 (1984), Abstract;

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