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m-Iodobenzylguanidine

ADP-ribosylation factor inhibitor
 
BML-G440-0010 10 mg 196.00 USD
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Competitive inhibitor of arginine specific mono-ADP-ribosyltransferase. IC50~100 µM. Blocks ADP-ribosylation-dependent signal transduction pathways.

Product Specification

Alternative Name:Iobenguane
 
Formula:C8H10IN3 . ½H2SO4
 
MW:324.1
 
CAS:80663-95-2
 
Purity:≥98% (HPLC,TLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Role of ADP-ribosylation in endothelial signal transduction and prostacyclin production: H. Halldorsson, et al.; FEBS Lett. 314, 322 (1992), Abstract;
Intracellular inhibition of mono(ADP-ribosylation) by meta-iodobenzylguanidine: specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis: L.A. Smets, et al.; Biochim. Biophys. Acta 1054, 49 (1990), Abstract;
Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation): C. Loesberg, et al.; Biochim. Biophys. Acta 1037, 92 (1990), Abstract;

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