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Ilimaquinone

ADP-ribosylation factor inhibitor
 
BML-G435-0100 100 µg 132.00 USD
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Replaces Prod. #: ALX-350-240

Displays antimicrobial, anti-HIV and anti-inflammatory properties. Induces complete and reversible breakdown of Golgi membranes. Inhibits the association of β-COP and ADP-ribosylation factor to Golgi membranes, but unlike BFA, does not induce retrograde transport of Golgi enzymes into ER or cause random fusion of successive Golgi cisternae. Interacts with methylation enzymes. Shows anticancer activity.

Product Specification

Alternative Name:3-[(Decahydro-1β,2β,4αβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
 
Formula:C22H30O4
 
MW:358.5
 
CAS:71678-03-0
 
Purity:≥98% (TLC)
 
Appearance:Yellow oil.
 
Solubility:25mg/ml soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Solutions can be stored at -20°C for up to 3 months.
 
ALX-350-240
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ALX-350-240

Product Literature References

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway: P.H. Lu, et al.; Eur. J. Pharmacol. 556, 45 (2007), Abstract;
Interaction of the smooth endoplasmic reticulum and mitochondria: J.G. Goetz & I.R. Nabi; Biochem. Soc. Trans. 34, 370 (2006), Review, Abstract;
Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport: V. Cruciani, et al.; Exp. Cell Res. 287, 130 (2003), Abstract;
Natural products with anti-HIV activity from marine organisms: L.A. Tziveleka, et al.; Curr. Top. Med. Chem. 3, 1512 (2003), Review, Abstract;
Interactions of (-)-ilimaquinone with methylation enzymes: implications for vesicular-mediated secretion: H.S. Radeke, et al.; Chem. Biol. 6, 639 (1999), Abstract;
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone: P.A. Takizawa, et al.; Cell 73, 1079 (1993), Abstract;
Microtubule independent vesiculation of Golgi membranes and the reassembly of vesicles into Golgi stacks: B. Veit, et al.; J. Cell. Biol. 122, 1197 (1993), Abstract;
Ilimaquinone, a sesquiterpenoid quinone from a marine sponge: R.T. Luibrand, et al.; Tetrahedron 35, 609 (1979),

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