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Mastoparan

Mast cell degranulating peptide
 
BML-G410-0001 1 mg 117.00 USD
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Replaces Prod. #: ALX-162-001

Cell permeable, amphiphilic, mast cell degranulating tetradecapeptide. Stimulates glycogenolysis and phospholipase D2 (PLD2) activity. Alters G-proteins in brain membranes. Directly activates G proteins by a mechanism analogous to that of G protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Stimulates exocytosis and phosphoinositide breakdown in a variety of cells. Inhibits calmodulin, and activates PLA2. Acts as a mitogen in Swiss 3T3 cells and stimulates pertussis toxin-sensitive arachidonate release without phosphoinositide breakdown.

Product Specification

Identity:Determined by MS.
 
Sequence:H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
 
Formula:C70H131N19O15
 
MW:1478.9
 
Source:Synthetic. Originally isolated from wasp venom (Vespula lewisii).
 
CAS:72093-21-1
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (1 mg/ml) or 100% ethanol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 

Product Literature References

Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci. 7, 501 (2006), Review, Abstract;
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol. 174, 4252 (2005), Abstract;
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem. 278, 12039 (2003), Abstract;
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol. 121, 1406 (1997), Abstract;
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta 1027, 185 (1990), Abstract;
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett. 260, 179 (1990), Abstract;
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem. 263, 6491 (1988), Abstract; Full Text
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull. 27, 1942 (1979), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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