Replaces Prod. #: ALX-430-103
Active carboxylate form of Lovastatin (Prod. No. BML-G226). Active in whole cells as well as cell-free assays. Inhibits cholesterol/ isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase.
Product Details
| Alternative Name: | Mevinolin . sodium salt, 6-α-Methylcompactin . sodium salt |
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| Formula: | C24H37O6 . Na |
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| MW: | 444.5 |
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| CAS: | 75225-50-2 |
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| MI: | 14: 5586 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (10mg/ml) or 100% ethanol (10mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cell cycle-specific effects of lovastatin: M. Jakobisiak, et al.; Proc Natl Acad Sci USA
88, 3628 (1991),
Abstract;
Inhibition of growth factor signaling pathways by lovastatin: T.S. Vincent, et al.; Biochem. Biophys. Res. Commun.
180, 1284 (1991),
Abstract;
Lovastatin blocks N-ras oncogene-induced neuronal differentiation: C.E. Mendola & J.M. Backer; Cell Growth Differ.
1, 499 (1990),
Abstract;
All ras proteins are polyisoprenylated but only some are palmitoylated: J.F. Hancock, et al.; Cell
57, 1167 (1989),
Abstract;
