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Simvastatin

HMG-CoA reductase inhibitor
 
BML-G244-0050 50 mg 125.00 USD
 
BML-G244-0250 250 mg 528.00 USD
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Replaces Prod. #: ALX-430-104

HMG-CoA reductase inhibitor. Synthetic analog of Lovastatin (Prod. No. BML-G226). Inhibits the biosynthesis of isoprenoids and prevents small G protein activation. Displays lipid lowering and antihypertensive effects. Displays antiinflammatory, immunomodulatory effects as well as protective effects in experimental traumatic brain injury. Activates Rac1-dependent signalling pathway.

Product Specification

Formula:C25H38O5
 
MW:418.6
 
CAS:79902-63-9
 
MI:14: 8539
 
RTECS:EK7798000
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml); insoluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Simvastatin prevents β-amyloid 25-35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate: C. Wang, et al.; Neuropharmacology 97, 122 (2015), Application(s): Oral administration to male mice, Abstract;
Beyond lipid lowering: the anti-hypertensive role of statins: V. Chopra, et al.; Cardiovasc. Drugs Ther. 21, 161 (2007), Abstract;
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury: H. Wang, et al.; Exp. Neurol. 206, 59 (2007), Abstract;
HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation: H. Xu, et al.; Am. J. Physiol. Renal Physiol. 291, F995 (2006), Abstract;
Anti-inflammatory and immunomodulatory effects of statins: L.M. Blanco-Colio, et al.; Kidney Int. 63, 12 (2003), Abstract;
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy: F.R. Danesh, et al.; Proc Natl Acad Sci USA 99, 8301 (2002), Abstract;
Lovastatin and simvastatin are modulators of the proteasome: C. Wojcik, et al.; Int. J. Biochem. Cell Biol. 32, 957 (2000), Abstract;

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