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Cerulenin

Fatty acid synthase inhibitor
 
BML-G237-0005 5 mg 95.00 USD
 
BML-G237-0025 25 mg 392.00 USD
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Replaces Prod. #: ALX-380-053

Antibiotic. Fatty acid synthase (FAS) inhibitor reported to bind in equimolar ratio to β-keto-acyl-ACP synthase (KAS; IC50=1.5µM), thus inhibiting protein acylation at concentrations of 45-134 µM. Produces metabolic effects similar to the effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes).

Product Specification

Alternative Name:2,3-Epoxy-4-oxo-7,10-dodecadienamide
 
Formula:C12H17NO3
 
MW:223.3
 
CAS:17397-89-6
 
MI:14: 2004
 
RTECS:JR1670000
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (>10mg/ml) or 100% ethanol (>10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
ALX-380-053
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ALX-380-053

Product Literature References

The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle: L. Zhou, et al.; Sci. Rep. 5, 13294 (2015), Application(s): Cell culture, Abstract;
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells: T.S. Ho, et al.; Biomed. Pharmacother. 61, 578 (2007), Abstract;
Expression and functional characterization of a giant Type I fatty acid synthase (CpFAS1) gene from Cryptosporidium parvum: G. Zhu, et al.; Mol. Biochem. Parasitol. 134, 127 (2004), Abstract;
Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase: R. Yasuno, et al.; J. Biol. Chem. 279, 8242 (2004), Abstract;
Key role of mitochondria in cerulenin-mediated apoptosis: S.J. Heiligtag, et al.; Cell Death Differ. 9, 1017 (2002), Abstract;
Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting: H. Makimura, et al.; Diabetes 50, 733 (2001), Abstract; Full Text
Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene: J. Inokashi, et al.; Mol. Gen. Genet. 244, 90 (1994), Abstract;
Effect of cerulenin on the synthesis of very-long-chain fatty acids in microsomes from leek seedlings: F. Schneider, et al.; Biochim. Biophys. Acta 1152, 243 (1993), Abstract;
Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins: S.A. Metz, et al.; Biochem. J. 295, 31 (1993), Abstract;
Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin: Y. Sato, et al.; J. Antibiot. (Tokyo) 200, 344 (1967), Abstract;

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