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B581

Farnesyltransferase inhibitor
 
BML-G235-0001 1 mg 155.00 USD
 
BML-G235-0005 5 mg 565.00 USD
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A potent and selective, cell-permeable farnesyl transferase inhibitor IC50=21 nM, 30-fold selective over geranylgeranyl transferase.

Product Specification

Formula:C22H38N4O3S2
 
MW:470.7
 
CAS:149759-96-6
 
Purity:≥98% (HPLC)
 
Identity:Determined by ESI-MS.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO (5mg/ml) or water (2mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation: A. D. Cox, et al.; J. Biol. Chem. 269, 19203 (1994), Abstract; Full Text
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells: M. A. Garcia, et al.; J. Biol. Chem. 268, 18415 (1993), Abstract; Full Text

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