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Mevastatin

HMG-CoA reductase inhibitor
 
BML-G233-0010 10 mg 74.00 USD
 
BML-G233-0050 50 mg 186.00 USD
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Mevastatin inhibits isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. It causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

Product Specification

Alternative Name:Compactin
 
Formula:C23H34O5
 
MW:390.5
 
CAS:73573-88-3
 
Purity:≥95% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (20mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

The discovery and development of HMG-CoA reductase inhibitors: A. Endo; J. Lipid Res. 33, 1569 (1992), Abstract;
The dual role of mevalonate in the cell cycle: V. Quesney-Huneeus, et al.; J. Biol. Chem. 258, 378 (1983), Abstract;
Essential role for mevalonate synthesis in DNA replication: V. Quesney-Huneeus, et al.; PNAS 76, 5056 (1979), Abstract;

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