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Lovastatin

HMG-CoA reductase inhibitor
 
BML-G226-0010 10 mg 53.00 USD
 
BML-G226-0050 50 mg 223.00 USD
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Inhibits cholesterol/isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase. Induces apoptosis in cancer cells.

Product Specification

Alternative Name:Mevinolin, 6-α-Methylcompactin
 
Formula:C24H36O5
 
MW:404.6
 
CAS:75330-75-5
 
MI:14: 5586
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>35mg/ml); insoluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Targeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth: E. D. Zanni, et al.; Oncotarget 8, 70695 (2017), Abstract; Full Text
Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells: M. Gioia, et al.; PLoS One 10, e0141270 (2015), Application(s): Cell Culture, Abstract; Full Text
Statins as a newly recognized type of immunomodulator: B. Kwak, et al.; Nat. Med. 6, 1399 (2000), Abstract;
Cell cycle-specific effects of lovastatin: M. Jakobisiak, et al.; Proc. Natl. Acad. Sci. USA 88, 3628 (1991), Abstract;
Inhibition of growth factor signaling pathways by lovastatin: T.S, Vincent, et al.; Biochem. Biophys. Res. Commun. 180, 1284 (1991), Abstract;
Lovastatin blocks N-ras oncogene-induced neuronal differentiation: C.E. Mendola & J.M. Backer; Cell Growth Differ. 1, 499 (1990), Abstract;
All ras proteins are polyisoprenylated but only some are palmitoylated: J.F. Hancock, et al.; Cell 57, 1167 (1989), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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