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Blocks methyl esterification of geranylgeranylated proteins
BML-G220-0005 5 mg 92.00 USD
BML-G220-0025 25 mg 356.00 USD
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Replaces Prod. #: ALX-290-008

AGGC specifically blocks methyl esterification of geranylgeranylated proteins such as Rab proteins. AGGC blocks receptor-mediated signal transduction in human neutrophils (IC50=4 µM). Induces insulin release from HIT-T15 cells by mimicking the action of Rab3A and inhibits β2-integrin-induced actin polymerization (IC50~45 nM) in neutrophils.

Product Specification

Purity:≥98% (TLC)
Appearance:Yellow viscous oil.
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
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Product Literature References

Inhibitors of farnesyl and geranylgeranyl methyltransferases prevent beta 2 integrin-induced actin polymerization without affecting beta 2 integrin-induced Ca2+ signaling in neutrophils: L. Molony, et al.; Biochem. Biophys. Res. Commun. 223, 612 (1996), Abstract;
Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide: R. Regazzi, et al.; Biochim. Biophys. Acta 1268, 269 (1995), Abstract;
Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils: M.R. Philips, et al.; Science 259, 977 (1993), Abstract;
A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues: C. Volker, et al.; FEBS Lett. 295, 189 (1991), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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