Replaces Prod. #: ALX-290-008
AGGC specifically blocks methyl esterification of geranylgeranylated proteins such as Rab proteins. AGGC blocks receptor-mediated signal transduction in human neutrophils (IC50=4 µM). Induces insulin release from HIT-T15 cells by mimicking the action of Rab3A and inhibits β2-integrin-induced actin polymerization (IC50~45 nM) in neutrophils.
Product Details
| Formula: | C25H41NO3S |
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| MW: | 435.7 |
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| CAS: | 139332-94-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow viscous oil. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitors of farnesyl and geranylgeranyl methyltransferases prevent beta 2 integrin-induced actin polymerization without affecting beta 2 integrin-induced Ca2+ signaling in neutrophils: L. Molony, et al.; Biochem. Biophys. Res. Commun.
223, 612 (1996),
Abstract;
Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide: R. Regazzi, et al.; Biochim. Biophys. Acta
1268, 269 (1995),
Abstract;
Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils: M.R. Philips, et al.; Science
259, 977 (1993),
Abstract;
A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues: C. Volker, et al.; FEBS Lett.
295, 189 (1991),
Abstract;
