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HBED

Potent iron chelator
 
BML-FR113-0050 50 mg 56.00 USD
 
BML-FR113-0250 250 mg 227.00 USD
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Iron chelator. Inhibits ferric ion catalyzed formation of hydroxyl radicals. A very potent ligand for the chelation of ferric iron in vivo (active in rat models but inactive in primate models). Inhibits neutrophil apoptosis. An important tool for probing the involvement of hydroxyl radicals in cellular processes.

Product Specification

Formula:C20H24N2O6 . HCl . H2O
 
MW:424.9
 
CAS:35369-53-0
 
Purity:≥95% (NMR)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml), in ethanol at 40°C (25mg/ml), in water (4mg/ml) at 50°C with vigorous agitation (approximately 15 minutes).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at 20°C for up to 3 months.
 
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Product Literature References

Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network: B. Faller, et al.; J. Med. Chem. 43, 1467 (2000), Abstract;
Hydroxyl radical as a potential intracellular mediator of polymorphonuclear neutrophil apoptosis: E. Rollet-Labelle, et al.; Free Radic. Biol. Med. 24, 563 (1998), Abstract;
Reactive oxygen species activate focal adhesion kinase, paxillin and p130cas tyrosine phosphorylation in endothelial cells: A. Gozin, et al.; Free Radic. Biol. Med. 25, 1021 (1998), Abstract;

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