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United States 

U-74389G

Blocks lipid peroxidation
 
BML-FR100-0100 100 mg 116.00 USD
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Replaces Prod. #: ALX-270-265

Lazaroid inhibitor of iron-dependent lipid peroxidation. Antioxidant. Inhibits lipid peroxidation in a variety of experimental systems including cultured brain microvessel endothlial cells, Cu2+ treated monocyclic THP1 cells and LLC-PK1 cell layers where it blocks F2 isoprostane production. Prevented organ damage in intestinal cold storage, preservation and reperfusion injury.

Product Specification

Alternative Name:21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate
 
Formula:C37H50N6O2 . C4H4O4
 
MW:726.9
 
CAS:153190-29-5
 
Purity:≥95% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml). Insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Hygroscopic.
 
ALX-270-265
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ALX-270-265

Product Literature References

UPLC-MS/MS Assay of 21-Aminosteroid (Lazaroid U74389G) for Application in Pharmacokinetic Study: P. Gadgil, et al.; J. Pharm. Biomed. Anal. 122, 90 (2016), Application(s): UPLC-MS/MS assay of lazaroid in rat plasma, Abstract;
Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice: K. Fukuma, et al.; Surgery 125, 421 (1999), Abstract;
Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia: R. Schmid-Elsaesser, et al.; Brain Res. 816, 471 (1999), Abstract; Full Text
The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock:: D. Altavilla, et al.; Eur. J. Pharmacol. 369, 49 (1999), Abstract;
Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats: D. Melchiorri, et al.; Life Sci. 62, 1927 (1998), Abstract;
Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2-. free radicals: A. Khalil, et al.; Life Sci. 63, 769 (1998), Abstract;
Protein oxidation biomarkers in hyperoxic lung injury in rats: effects of U-74389: S. Awasthi, et al.; Toxicol. Lett. 95, 47 (1998), Abstract;
The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain: R.H. Fabian, et al.; J. Neurotrauma 15, 433 (1998), Abstract;
Comparison of various lazaroid compounds for protection against ischemic liver injury: N. Ishizaki, et al.; Transplantation 63, 202 (1997), Abstract;
Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation: G.M. Campo, et al.; J. Pharmacol. Exp. Ther. 277, 333 (1996), Abstract;
Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G: A.M. Perna, et al.; Pharmacol. Res. 34, 25 (1996), Abstract;
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers: F. Shi, et al.; Free Radic. Biol. Med. 19, 349 (1995), Abstract;
Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants: D.J. Crutchley & B.G. Que; Circulation 92, 238 (1995), Abstract;
Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol. 6, 1300 (1995), Abstract;
Improved small intestinal preservation after lazaroid U74389G treatment and cold storage in University of Wisconsin solution: S.M. Katz, et al.; Transplantation 59, 694 (1995), Abstract;

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