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Eicosapentaenoyl ethanolamide

 
BML-FA047-0025 25 mg 181.00 USD
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Has been shown to inhibit dietary-restriction-induced lifespan extension in wild-type and TOR pathway mutant nematodes. This data indicates that reduced N-acylethanolamide signaling mediates some of the effect of dietary-restriction-induced lifespan extension and that EPEA, specifically, acts as a metabolic signal that couples nutrient availability with growth and lifespan. EPEA has also been shown to have anti-proliferative effects and anti-inflammatory properties. Compound is subject to oxidation. Protect from air.

Product Specification

Alternative Name:EPEA
 
Formula:C22H35NO2
 
MW:345.5
 
Source:Synthetic.
 
CAS:109001-03-8
 
Purity:≥98% (TLC)
 
Appearance:Pale amber oil.
 
Solubility:Soluble in DMSO (20mg/ml) or in 100% ethanol (25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least one year after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months.
 
Handling:Protect from air.
 
BML-FA047 Structure
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BML-FA047 Structure

Product Literature References

N-acylethanolamine signaling mediates the effect of diet on lifespan in Caenorhabditis elegans: M. Lucanic, et al.; Nature 473, 226 (2011), Abstract;
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3-ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines : I. Brown, et al. ; Carcinogenesis 31, 1584 (2010), Abstract;
Docosahexaenoic and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acylethanolamines with anti-inflammatory properties: M. Balvers, et al.; Biochim. Biophys. Acta 1801, 1107 (2010), Abstract;

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