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N-Oleoyl-L-serine

Promotes osteoclast proliferation
 
BML-FA046-0025 25 mg 275.00 USD
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N-Oleoy-L-serine was isolated from mouse brain and trabecular bone and was determined to be the L-isomer. It was shown to promote the growth and proliferation of MC3T3 E1 osteoblasts at 10-11M via a pertusis toxin-sensitive mechanism and transiently induced ERK1/2 phosphorylation. It inhibited osteoclast formation in vitro and in an ovariectomy-induced bone loss model, it induced complete rescue after 12 weeks (5mg/kg).

Product Specification

Formula:C21H39NO4
 
MW:369.5
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (15 mg/ml) or ethanol (6 mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-FA046 structure
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BML-FA046 structure

Product Literature References

Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors: A. Scott & E. M. Williamson; Calcif. Tissue Int. 80, 50 (2007), Abstract;

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