N-Arachidonoyl-L-serine

Endocannabinoid; vasodilator



BML-FA037-0010	10 mg	64.00 USD

BML-FA037-0050	50 mg	263.00 USD

Replaces Prod. #: ALX-340-063

N-Arachidonoyl-L-serine is an endocannabinoid isolated from bovine brain. It binds only very weakly to cannabinoid CB₁ and CB₂ receptors as well as vannilloid TRPV1 receptors. However, it produces endothelium-dependent vasodilation in rat isolated mesenteric arteries and abdominal aorta. It also suppresses LPS-induced TNFα production in a murine macrophage cell line and in mice. Its biological profile closely parallels that of abnormal cannabidiol an agonist at a putative novel cannabinoid-like receptor.

Formula:	C₂₃H₃₇NO₄

MW:	391.5

Purity:	≥98% (TLC)

Appearance:	Colorless oil.

CAS:	187224-29-9

Solubility:	Soluble in DMSO (4mg/ml) or dimethyl formamide; sparingly soluble in water.

Long Term Storage:	-80°C

Background / Technical Information:	Please click here for the comprehensive product datasheet.

Please mouse over

Product Literature References

N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties: G. Milman, et al.; PNAS 103, 2428 (2006), Abstract;