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Arachidonyl-2-chloroethylamide

Cannabinoid receptor ligand
 
BML-FA032-0050 50 mg 364.00 USD
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Replaces Prod. #: ALX-340-053

Non-pungent, potent and highly selective agonist of the cannabinoid CB1 receptor (Ki=1.4nM). Displays >1’400-fold selectivity over CB2 receptors (Ki=3.1µM). Active in vivo.

Product Specification

Alternative Name:ACEA, N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
 
Formula:C22H36NOCl
 
MW:366.0
 
CAS:220556-69-4
 
Purity:≥98% (TLC)
 
Appearance:Pale yellow oil.
 
Solubility:Soluble in DMSO (25mg/ml) or ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C when stored under an inert atmosphere.
 
Handling:Protect from air. Keep under inert gas.
 
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Product Literature References

Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide: T.J. Price, et al.; Br. J. Pharmacol. 141, 1118 (2004), Abstract;
The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints: C.L. Baker and J.J. McDougall; Br. J. Pharmacol. 142, 1361 (2004), Abstract; Full Text
Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors: A. Franklin, et al.; Eur. J. Pharmacol. 474, 195 (2003), Abstract;
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1): C.J. Hillard, et al.; J. Pharmacol. Exp. Ther. 289, 1427 (1999), Abstract;

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